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Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expend...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434857/ https://www.ncbi.nlm.nih.gov/pubmed/30909971 http://dx.doi.org/10.1186/s13041-019-0444-5 |
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author | Shan, Chang Ghosh, Arijit Guo, Xing-zhi Wang, Shu-min Hou, Yan-fang Li, Sheng-tian Liu, Jian-min |
author_facet | Shan, Chang Ghosh, Arijit Guo, Xing-zhi Wang, Shu-min Hou, Yan-fang Li, Sheng-tian Liu, Jian-min |
author_sort | Shan, Chang |
collection | PubMed |
description | It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies. |
format | Online Article Text |
id | pubmed-6434857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64348572019-04-08 Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders Shan, Chang Ghosh, Arijit Guo, Xing-zhi Wang, Shu-min Hou, Yan-fang Li, Sheng-tian Liu, Jian-min Mol Brain Review It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies. BioMed Central 2019-03-25 /pmc/articles/PMC6434857/ /pubmed/30909971 http://dx.doi.org/10.1186/s13041-019-0444-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Shan, Chang Ghosh, Arijit Guo, Xing-zhi Wang, Shu-min Hou, Yan-fang Li, Sheng-tian Liu, Jian-min Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title_full | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title_fullStr | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title_full_unstemmed | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title_short | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
title_sort | roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434857/ https://www.ncbi.nlm.nih.gov/pubmed/30909971 http://dx.doi.org/10.1186/s13041-019-0444-5 |
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