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Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders

It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expend...

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Autores principales: Shan, Chang, Ghosh, Arijit, Guo, Xing-zhi, Wang, Shu-min, Hou, Yan-fang, Li, Sheng-tian, Liu, Jian-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434857/
https://www.ncbi.nlm.nih.gov/pubmed/30909971
http://dx.doi.org/10.1186/s13041-019-0444-5
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author Shan, Chang
Ghosh, Arijit
Guo, Xing-zhi
Wang, Shu-min
Hou, Yan-fang
Li, Sheng-tian
Liu, Jian-min
author_facet Shan, Chang
Ghosh, Arijit
Guo, Xing-zhi
Wang, Shu-min
Hou, Yan-fang
Li, Sheng-tian
Liu, Jian-min
author_sort Shan, Chang
collection PubMed
description It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies.
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spelling pubmed-64348572019-04-08 Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders Shan, Chang Ghosh, Arijit Guo, Xing-zhi Wang, Shu-min Hou, Yan-fang Li, Sheng-tian Liu, Jian-min Mol Brain Review It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies. BioMed Central 2019-03-25 /pmc/articles/PMC6434857/ /pubmed/30909971 http://dx.doi.org/10.1186/s13041-019-0444-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Shan, Chang
Ghosh, Arijit
Guo, Xing-zhi
Wang, Shu-min
Hou, Yan-fang
Li, Sheng-tian
Liu, Jian-min
Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title_full Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title_fullStr Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title_full_unstemmed Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title_short Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
title_sort roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434857/
https://www.ncbi.nlm.nih.gov/pubmed/30909971
http://dx.doi.org/10.1186/s13041-019-0444-5
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