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Structural and functional properties of Grb2 SH2 dimer in CD28 binding

Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein that plays a critical role in cellular signal transduction. It contains a central Src homology 2 (SH2) domain flanked by two Src homology 3 (SH3) domains. Binding of Grb2 SH2 to the cytoplasmic region of CD28, phosphorylated Tyr (pY...

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Detalles Bibliográficos
Autores principales:	Hosoe, Yuhi, Numoto, Nobutaka, Inaba, Satomi, Ogawa, Shuhei, Morii, Hisayuki, Abe, Ryo, Ito, Nobutoshi, Oda, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2019
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435016/ https://www.ncbi.nlm.nih.gov/pubmed/30923665 http://dx.doi.org/10.2142/biophysico.16.0_80

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