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Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma
The immune system employs several checkpoint pathways to regulate responses, maintain homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these protective mechanisms to enable immune escape, cancer survival and proliferation. Blocking antibodies, designed to interfere wi...
Autores principales: | Khair, Duaa O., Bax, Heather J., Mele, Silvia, Crescioli, Silvia, Pellizzari, Giulia, Khiabany, Atousa, Nakamura, Mano, Harris, Robert J., French, Elise, Hoffmann, Ricarda M., Williams, Iwan P., Cheung, Anthony, Thair, Benjamin, Beales, Charlie T., Touizer, Emma, Signell, Adrian W., Tasnova, Nahrin L., Spicer, James F., Josephs, Debra H., Geh, Jenny L., MacKenzie Ross, Alastair, Healy, Ciaran, Papa, Sophie, Lacy, Katie E., Karagiannis, Sophia N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435047/ https://www.ncbi.nlm.nih.gov/pubmed/30941125 http://dx.doi.org/10.3389/fimmu.2019.00453 |
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