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Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435101/ https://www.ncbi.nlm.nih.gov/pubmed/30735826 http://dx.doi.org/10.1016/j.neuroimage.2019.02.007 |
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author | Metzler-Baddeley, Claudia Mole, Jilu P. Leonaviciute, Erika Sims, Rebecca Kidd, Emma J. Ertefai, Benyamin Kelso-Mitchell, Aurora Gidney, Florence Fasano, Fabrizio Evans, John Jones, Derek K. Baddeley, Roland J. |
author_facet | Metzler-Baddeley, Claudia Mole, Jilu P. Leonaviciute, Erika Sims, Rebecca Kidd, Emma J. Ertefai, Benyamin Kelso-Mitchell, Aurora Gidney, Florence Fasano, Fabrizio Evans, John Jones, Derek K. Baddeley, Roland J. |
author_sort | Metzler-Baddeley, Claudia |
collection | PubMed |
description | Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38–71 years old). We employed MRI indices sensitive to myelin and neuroinflammation [macromolecular proton fraction (MPF) and k(f)] from quantitative magnetization transfer (qMT) together with indices from neurite orientation dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal cingulum, uncinate fasciculus (compared with whole brain white matter and corticospinal tract) and the hippocampus. Central obesity was assessed with the Waist Hip Ratio (WHR) and abdominal visceral and subcutaneous fat area fractions (VFF, SFF), and systemic inflammation with blood plasma concentrations of leptin, adiponectin, C-reactive protein and interleukin 8. Men were significantly more centrally obese and had higher VFF than women. Individual differences in WHR and in VFF were negatively correlated with differences in fornix MPF and k(f), but not with any differences in neurite microstructure. In women, age mediated the effects of VFF on fornix MPF and k(f), whilst in men differences in the leptin and adiponectin ratio fully mediated the effect of WHR on fornix MPF. These results suggest that visceral fat related systemic inflammation may damage myelin-related properties of the fornix, a key limbic structure known to be involved in LOAD. |
format | Online Article Text |
id | pubmed-6435101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-64351012019-04-08 Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure Metzler-Baddeley, Claudia Mole, Jilu P. Leonaviciute, Erika Sims, Rebecca Kidd, Emma J. Ertefai, Benyamin Kelso-Mitchell, Aurora Gidney, Florence Fasano, Fabrizio Evans, John Jones, Derek K. Baddeley, Roland J. Neuroimage Article Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38–71 years old). We employed MRI indices sensitive to myelin and neuroinflammation [macromolecular proton fraction (MPF) and k(f)] from quantitative magnetization transfer (qMT) together with indices from neurite orientation dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal cingulum, uncinate fasciculus (compared with whole brain white matter and corticospinal tract) and the hippocampus. Central obesity was assessed with the Waist Hip Ratio (WHR) and abdominal visceral and subcutaneous fat area fractions (VFF, SFF), and systemic inflammation with blood plasma concentrations of leptin, adiponectin, C-reactive protein and interleukin 8. Men were significantly more centrally obese and had higher VFF than women. Individual differences in WHR and in VFF were negatively correlated with differences in fornix MPF and k(f), but not with any differences in neurite microstructure. In women, age mediated the effects of VFF on fornix MPF and k(f), whilst in men differences in the leptin and adiponectin ratio fully mediated the effect of WHR on fornix MPF. These results suggest that visceral fat related systemic inflammation may damage myelin-related properties of the fornix, a key limbic structure known to be involved in LOAD. Academic Press 2019-04-01 /pmc/articles/PMC6435101/ /pubmed/30735826 http://dx.doi.org/10.1016/j.neuroimage.2019.02.007 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Metzler-Baddeley, Claudia Mole, Jilu P. Leonaviciute, Erika Sims, Rebecca Kidd, Emma J. Ertefai, Benyamin Kelso-Mitchell, Aurora Gidney, Florence Fasano, Fabrizio Evans, John Jones, Derek K. Baddeley, Roland J. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title | Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title_full | Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title_fullStr | Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title_full_unstemmed | Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title_short | Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
title_sort | sex-specific effects of central adiposity and inflammatory markers on limbic microstructure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435101/ https://www.ncbi.nlm.nih.gov/pubmed/30735826 http://dx.doi.org/10.1016/j.neuroimage.2019.02.007 |
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