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Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure

Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated t...

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Autores principales: Metzler-Baddeley, Claudia, Mole, Jilu P., Leonaviciute, Erika, Sims, Rebecca, Kidd, Emma J., Ertefai, Benyamin, Kelso-Mitchell, Aurora, Gidney, Florence, Fasano, Fabrizio, Evans, John, Jones, Derek K., Baddeley, Roland J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435101/
https://www.ncbi.nlm.nih.gov/pubmed/30735826
http://dx.doi.org/10.1016/j.neuroimage.2019.02.007
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author Metzler-Baddeley, Claudia
Mole, Jilu P.
Leonaviciute, Erika
Sims, Rebecca
Kidd, Emma J.
Ertefai, Benyamin
Kelso-Mitchell, Aurora
Gidney, Florence
Fasano, Fabrizio
Evans, John
Jones, Derek K.
Baddeley, Roland J.
author_facet Metzler-Baddeley, Claudia
Mole, Jilu P.
Leonaviciute, Erika
Sims, Rebecca
Kidd, Emma J.
Ertefai, Benyamin
Kelso-Mitchell, Aurora
Gidney, Florence
Fasano, Fabrizio
Evans, John
Jones, Derek K.
Baddeley, Roland J.
author_sort Metzler-Baddeley, Claudia
collection PubMed
description Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38–71 years old). We employed MRI indices sensitive to myelin and neuroinflammation [macromolecular proton fraction (MPF) and k(f)] from quantitative magnetization transfer (qMT) together with indices from neurite orientation dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal cingulum, uncinate fasciculus (compared with whole brain white matter and corticospinal tract) and the hippocampus. Central obesity was assessed with the Waist Hip Ratio (WHR) and abdominal visceral and subcutaneous fat area fractions (VFF, SFF), and systemic inflammation with blood plasma concentrations of leptin, adiponectin, C-reactive protein and interleukin 8. Men were significantly more centrally obese and had higher VFF than women. Individual differences in WHR and in VFF were negatively correlated with differences in fornix MPF and k(f), but not with any differences in neurite microstructure. In women, age mediated the effects of VFF on fornix MPF and k(f), whilst in men differences in the leptin and adiponectin ratio fully mediated the effect of WHR on fornix MPF. These results suggest that visceral fat related systemic inflammation may damage myelin-related properties of the fornix, a key limbic structure known to be involved in LOAD.
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spelling pubmed-64351012019-04-08 Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure Metzler-Baddeley, Claudia Mole, Jilu P. Leonaviciute, Erika Sims, Rebecca Kidd, Emma J. Ertefai, Benyamin Kelso-Mitchell, Aurora Gidney, Florence Fasano, Fabrizio Evans, John Jones, Derek K. Baddeley, Roland J. Neuroimage Article Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38–71 years old). We employed MRI indices sensitive to myelin and neuroinflammation [macromolecular proton fraction (MPF) and k(f)] from quantitative magnetization transfer (qMT) together with indices from neurite orientation dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal cingulum, uncinate fasciculus (compared with whole brain white matter and corticospinal tract) and the hippocampus. Central obesity was assessed with the Waist Hip Ratio (WHR) and abdominal visceral and subcutaneous fat area fractions (VFF, SFF), and systemic inflammation with blood plasma concentrations of leptin, adiponectin, C-reactive protein and interleukin 8. Men were significantly more centrally obese and had higher VFF than women. Individual differences in WHR and in VFF were negatively correlated with differences in fornix MPF and k(f), but not with any differences in neurite microstructure. In women, age mediated the effects of VFF on fornix MPF and k(f), whilst in men differences in the leptin and adiponectin ratio fully mediated the effect of WHR on fornix MPF. These results suggest that visceral fat related systemic inflammation may damage myelin-related properties of the fornix, a key limbic structure known to be involved in LOAD. Academic Press 2019-04-01 /pmc/articles/PMC6435101/ /pubmed/30735826 http://dx.doi.org/10.1016/j.neuroimage.2019.02.007 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Metzler-Baddeley, Claudia
Mole, Jilu P.
Leonaviciute, Erika
Sims, Rebecca
Kidd, Emma J.
Ertefai, Benyamin
Kelso-Mitchell, Aurora
Gidney, Florence
Fasano, Fabrizio
Evans, John
Jones, Derek K.
Baddeley, Roland J.
Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title_full Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title_fullStr Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title_full_unstemmed Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title_short Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
title_sort sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435101/
https://www.ncbi.nlm.nih.gov/pubmed/30735826
http://dx.doi.org/10.1016/j.neuroimage.2019.02.007
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