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Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment

Cancer is a major public health problem, and is now the world’s leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems ha...

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Detalles Bibliográficos
Autores principales: Ma, Zhe, Fan, Yuqi, Wu, Yumei, Kebebe, Dereje, Zhang, Bing, Lu, Peng, Pi, Jiaxin, Liu, Zhidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435121/
https://www.ncbi.nlm.nih.gov/pubmed/30962686
http://dx.doi.org/10.2147/IJN.S197889
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author Ma, Zhe
Fan, Yuqi
Wu, Yumei
Kebebe, Dereje
Zhang, Bing
Lu, Peng
Pi, Jiaxin
Liu, Zhidong
author_facet Ma, Zhe
Fan, Yuqi
Wu, Yumei
Kebebe, Dereje
Zhang, Bing
Lu, Peng
Pi, Jiaxin
Liu, Zhidong
author_sort Ma, Zhe
collection PubMed
description Cancer is a major public health problem, and is now the world’s leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of >280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.
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spelling pubmed-64351212019-04-08 Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment Ma, Zhe Fan, Yuqi Wu, Yumei Kebebe, Dereje Zhang, Bing Lu, Peng Pi, Jiaxin Liu, Zhidong Int J Nanomedicine Review Cancer is a major public health problem, and is now the world’s leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of >280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies. Dove Medical Press 2019-03-22 /pmc/articles/PMC6435121/ /pubmed/30962686 http://dx.doi.org/10.2147/IJN.S197889 Text en © 2019 Ma et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Ma, Zhe
Fan, Yuqi
Wu, Yumei
Kebebe, Dereje
Zhang, Bing
Lu, Peng
Pi, Jiaxin
Liu, Zhidong
Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title_full Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title_fullStr Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title_full_unstemmed Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title_short Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
title_sort traditional chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435121/
https://www.ncbi.nlm.nih.gov/pubmed/30962686
http://dx.doi.org/10.2147/IJN.S197889
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