Meso scale discovery-based assays for the detection of aggregated huntingtin

Huntington’s disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT (mHTT) protein is highly prone to intracellular ag...

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Detalles Bibliográficos
Autores principales: Reindl, Wolfgang, Baldo, Barbara, Schulz, Jana, Janack, Isabell, Lindner, Ilka, Kleinschmidt, Markus, Sedaghat, Yalda, Thiede, Christina, Tillack, Karsten, Schmidt, Christina, Cardaun, Isabell, Schwagarus, Tom, Herrmann, Frank, Hotze, Madlen, Osborne, Georgina F., Herrmann, Simone, Weiss, Andreas, Zerbinatti, Celina, Bates, Gillian P., Bard, Jonathan, Munoz-Sanjuan, Ignacio, Macdonald, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435127/
https://www.ncbi.nlm.nih.gov/pubmed/30913220
http://dx.doi.org/10.1371/journal.pone.0213521

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