Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (T(H)1)/T(H)17 responses and autoimmunity

N-acetylglucosamine (GlcNAc) branching of Asn (N)–linked glycans inhibits pro-inflammatory T cell responses and models of autoimmune diseases such as Multiple Sclerosis (MS). Metabolism controls N-glycan branching in T cells by regulating de novo hexosamine pathway biosynthesis of UDP-GlcNAc, the do...

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Detalles Bibliográficos
Autores principales: Lee, Sung-Uk, Li, Carey F., Mortales, Christie-Lynn, Pawling, Judy, Dennis, James W., Grigorian, Ani, Demetriou, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435169/
https://www.ncbi.nlm.nih.gov/pubmed/30913278
http://dx.doi.org/10.1371/journal.pone.0214253

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