Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8(+) T cell effector function

Varicella zoster virus (VZV) is a lymphotropic alpha-herpesvirinae subfamily member that produces varicella on primary infection and causes zoster, vascular disease and vision loss upon reactivation from latency. VZV-infected peripheral blood mononuclear cells (PBMCs) disseminate virus to distal org...

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Detalles Bibliográficos
Autores principales: Jones, Dallas, Como, Christina N., Jing, Lichen, Blackmon, Anna, Neff, Charles Preston, Krueger, Owen, Bubak, Andrew N., Palmer, Brent E., Koelle, David M., Nagel, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435197/
https://www.ncbi.nlm.nih.gov/pubmed/30870532
http://dx.doi.org/10.1371/journal.ppat.1007650

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