Cargando…

A potently neutralizing human monoclonal antibody targeting an epitope in the West Nile virus E protein preferentially recognizes mature virions

West Nile virus (WNV), a member of the Flavivirus genus, is a leading cause of viral encephalitis in the United States(1). The development of neutralizing antibodies against the flavivirus envelope (E) protein is critical for immunity and vaccine protection(2). Previously identified candidate therap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goo, Leslie, Debbink, Kari, Kose, Nurgun, Sapparapu, Gopal, Doyle, Michael P., Wessel, Alex W., Richner, Justin M., Burgomaster, Katherine E., Larman, Bridget C., Dowd, Kimberly A., Diamond, Michael S., Crowe, James E., Pierson, Theodore C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435290/ https://www.ncbi.nlm.nih.gov/pubmed/30455471 http://dx.doi.org/10.1038/s41564-018-0283-7

Ejemplares similares

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus
por: Fernandez, Estefania, et al.
Publicado: (2018)

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
por: Wessel, Alex W., et al.
Publicado: (2021)

prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis
por: A. Dowd, Kimberly, et al.
Publicado: (2023)

Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA
por: Geiss, Brian J, et al.
Publicado: (2005)

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope
por: Austin, S. Kyle, et al.
Publicado: (2012)

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis
por: Goo, Leslie, et al.
Publicado: (2017)

Distinguishing West Nile virus infection using a recombinant envelope protein with mutations in the conserved fusion-loop
por: Chabierski, Stefan, et al.
Publicado: (2014)

A Dynamic Landscape for Antibody Binding Modulates Antibody-Mediated Neutralization of West Nile Virus
por: Dowd, Kimberly A., et al.
Publicado: (2011)

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
por: Mousa, Jarrod J., et al.
Publicado: (2017)

Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy
por: Wessel, Alex W., et al.
Publicado: (2020)

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface
por: Fibriansah, Guntur, et al.
Publicado: (2014)

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization
por: Giordano, Daniela, et al.
Publicado: (2017)

Antibody Responses in Humans Infected with Newly Emerging Strains of West Nile Virus in Europe
por: Chabierski, Stefan, et al.
Publicado: (2013)

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth
por: Chukwuma, Valentine U., et al.
Publicado: (2018)

Virus and Host Determinants of West Nile Virus Pathogenesis
por: Diamond, Michael S.
Publicado: (2009)

Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization
por: Nelson, Steevenson, et al.
Publicado: (2008)

Identification of host tRNAs preferentially recognized by the Plasmodium surface protein tRip
por: Cela, Marta, et al.
Publicado: (2021)

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection
por: Bennett, Allison K., et al.
Publicado: (2023)

A human antibody against Zika virus crosslinks the E protein to prevent infection
por: Hasan, S. Saif, et al.
Publicado: (2017)

Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease
por: Powell, Laura A., et al.
Publicado: (2020)

2593. Human Monoclonal Antibodies Potently Neutralize Enterovirus D68 in both a Clade-Specific and -Independent Manner
por: Vogt, Matthew R, et al.
Publicado: (2019)

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice
por: Salazar, Vanessa, et al.
Publicado: (2019)

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
por: Wu, Shang-Chuen, et al.
Publicado: (2021)

Experimental Infection of Rhesus Macaques and Common Marmosets with a European Strain of West Nile Virus
por: Verstrepen, Babs E., et al.
Publicado: (2014)

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection
por: Richner, Justin M., et al.
Publicado: (2015)

Immune Responses to West Nile Virus Infection in the Central Nervous System
por: Cho, Hyelim, et al.
Publicado: (2012)

Creating a ribonuclease T-tat that preferentially recognizes and hydrolyzes HIV-1 TAR RNA in vitro and in vivo
por: Dow-Tien, Chen, et al.
Publicado: (2008)

Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae
por: Walvoort, Marthe T. C., et al.
Publicado: (2016)

Metabolic Value Chemoattractants Are Preferentially Recognized at Broad Ligand Range Chemoreceptor of Pseudomonas putida KT2440
por: Fernández, Matilde, et al.
Publicado: (2017)

G1-like M and PB2 genes are preferentially incorporated into H7N9 progeny virions during genetic reassortment
por: Li, Xiuli, et al.
Publicado: (2021)

Vaccination of Mice Using the West Nile Virus E-Protein in a DNA Prime-Protein Boost Strategy Stimulates Cell-Mediated Immunity and Protects Mice against a Lethal Challenge
por: De Filette, Marina, et al.
Publicado: (2014)

Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus
por: Doyle, Michael P., et al.
Publicado: (2022)

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding
por: Sapparapu, Gopal, et al.
Publicado: (2016)

Virion Structure and Composition
por: Burrell, Christopher J., et al.
Publicado: (2017)

B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
por: Austin, S. Kyle, et al.
Publicado: (2014)

Erratum: Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae
por: Walvoort, Marthe T. C., et al.
Publicado: (2017)

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections
por: Gilchuk, Iuliia, et al.
Publicado: (2016)

Protective immune responses against West Nile virus are primed by distinct complement activation pathways
por: Mehlhop, Erin, et al.
Publicado: (2006)

BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION
por: Flyak, Andrew I., et al.
Publicado: (2018)

Proteomic analysis of the EhV-86 virion
por: Allen, Michael J, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_01hn1o15t00hjv5elfdo8ll8fj