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The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

RNA polymerase (Pol) I is a 14-subunit enzyme that solely transcribes pre-ribosomal RNA. Cryo-electron microscopy (EM) structures of Pol I initiation and elongation complexes have given first insights into the molecular mechanisms of Pol I transcription. Here, we present cryo-EM structures of yeast...

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Detalles Bibliográficos
Autores principales:	Tafur, Lucas, Sadian, Yashar, Hanske, Jonas, Wetzel, Rene, Weis, Felix, Müller, Christoph W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435322/ https://www.ncbi.nlm.nih.gov/pubmed/30913026 http://dx.doi.org/10.7554/eLife.43204

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