Microglial SIRPα regulates the emergence of CD11c(+) microglia and demyelination damage in white matter

A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c(+) microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of signal regulatory protein α (SIRPα), a membrane...

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Detalles Bibliográficos
Autores principales: Sato-Hashimoto, Miho, Nozu, Tomomi, Toriba, Riho, Horikoshi, Ayano, Akaike, Miho, Kawamoto, Kyoko, Hirose, Ayaka, Hayashi, Yuriko, Nagai, Hiromi, Shimizu, Wakana, Saiki, Ayaka, Ishikawa, Tatsuya, Elhanbly, Ruwaida, Kotani, Takenori, Murata, Yoji, Saito, Yasuyuki, Naruse, Masae, Shibasaki, Koji, Oldenborg, Per-Arne, Jung, Steffen, Matozaki, Takashi, Fukazawa, Yugo, Ohnishi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435324/
https://www.ncbi.nlm.nih.gov/pubmed/30910011
http://dx.doi.org/10.7554/eLife.42025

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