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DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance on DNA/RNA, making PTs a valuable biochemical and pharmacological tool. In...

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Detalles Bibliográficos
Autores principales:	Wang, Lianrong, Jiang, Susu, Deng, Zixin, Dedon, Peter C, Chen, Shi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435447/ https://www.ncbi.nlm.nih.gov/pubmed/30289455 http://dx.doi.org/10.1093/femsre/fuy036

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