High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling

Experimental studies show that the unsaturated high-fat diet-induced obesity promotes vascular alterations characterized by improving the endothelial L-arginine/Nitric Oxide (NO) pathway. Leptin seems to be involved in this process, promoting vasodilation via increasing NO bioavailability. The aim o...

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Detalles Bibliográficos
Autores principales: Rocha, Vanessa da Silva, Claudio, Erick Roberto Gonçalves, da Silva, Vitor Loureiro, Cordeiro, Jóctan Pimentel, Domingos, Lucas Furtado, da Cunha, Márcia Regina Holanda, Mauad, Helder, do Nascimento, Thiago Bruder, Lima-Leopoldo, Ana Paula, Leopoldo, André Soares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435481/
https://www.ncbi.nlm.nih.gov/pubmed/30949067
http://dx.doi.org/10.3389/fphys.2019.00268

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