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Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population
Intervertebral disc degeneration (IDD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing the production of extracellular matrix degradation en...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435502/ https://www.ncbi.nlm.nih.gov/pubmed/29884765 http://dx.doi.org/10.1042/BSR20171627 |
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author | Chen, Yimin Ma, Haitao Bi, Dawei Qiu, Binsong |
author_facet | Chen, Yimin Ma, Haitao Bi, Dawei Qiu, Binsong |
author_sort | Chen, Yimin |
collection | PubMed |
description | Intervertebral disc degeneration (IDD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing the production of extracellular matrix degradation enzymes and by inhibiting extracellular matrix synthesis. IL-1α may provide insight about the etiology of IDD. We performed a hospital-based case–control study involving 200 IDD patients and 200 controls in the Chinese Han population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit. Our study indicated that IL-1α -899C/T polymorphism could increase the risk of IDD under the homozygous, recessive, and allelic models. Subsequently, we validated this significant association by a meta-analysis. Stratification analysis of ethnicity in this meta-analysis also obtained a significant association among Asians and Caucasians. In conclusion, the present study finds that IL-1α -899C/T polymorphism is associated with the risk of IDD. Larger studies with more diverse ethnic populations are needed to confirm these results. |
format | Online Article Text |
id | pubmed-6435502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64355022019-04-12 Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population Chen, Yimin Ma, Haitao Bi, Dawei Qiu, Binsong Biosci Rep Research Articles Intervertebral disc degeneration (IDD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing the production of extracellular matrix degradation enzymes and by inhibiting extracellular matrix synthesis. IL-1α may provide insight about the etiology of IDD. We performed a hospital-based case–control study involving 200 IDD patients and 200 controls in the Chinese Han population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit. Our study indicated that IL-1α -899C/T polymorphism could increase the risk of IDD under the homozygous, recessive, and allelic models. Subsequently, we validated this significant association by a meta-analysis. Stratification analysis of ethnicity in this meta-analysis also obtained a significant association among Asians and Caucasians. In conclusion, the present study finds that IL-1α -899C/T polymorphism is associated with the risk of IDD. Larger studies with more diverse ethnic populations are needed to confirm these results. Portland Press Ltd. 2018-07-06 /pmc/articles/PMC6435502/ /pubmed/29884765 http://dx.doi.org/10.1042/BSR20171627 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Chen, Yimin Ma, Haitao Bi, Dawei Qiu, Binsong Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title | Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title_full | Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title_fullStr | Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title_full_unstemmed | Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title_short | Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population |
title_sort | association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the chinese han population |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435502/ https://www.ncbi.nlm.nih.gov/pubmed/29884765 http://dx.doi.org/10.1042/BSR20171627 |
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