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Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca(2+)-influx, LTP impairment and neurotoxicity
Amyloid protein misfolding results in a self-assembling aggregation process, characterized by the formation of typical aggregates. The attention is focused on pre-fibrillar oligomers (PFOs), formed in the early stages and supposed to be neurotoxic. PFOs structure may change due to their instability...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435710/ https://www.ncbi.nlm.nih.gov/pubmed/30914688 http://dx.doi.org/10.1038/s41598-019-41462-0 |