Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

Acetyl-CoA is a fundamental metabolite for all life on Earth, and is also a key starting point for the biosynthesis of a variety of industrial chemicals and natural products. Here we design and construct a Synthetic Acetyl-CoA (SACA) pathway by repurposing glycolaldehyde synthase and acetyl-phosphat...

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Detalles Bibliográficos
Autores principales: Lu, Xiaoyun, Liu, Yuwan, Yang, Yiqun, Wang, Shanshan, Wang, Qian, Wang, Xiya, Yan, Zhihui, Cheng, Jian, Liu, Cui, Yang, Xue, Luo, Hao, Yang, Sheng, Gou, Junran, Ye, Luzhen, Lu, Lina, Zhang, Zhidan, Guo, Yu, Nie, Yan, Lin, Jianping, Li, Sheng, Tian, Chaoguang, Cai, Tao, Zhuo, Bingzhao, Ma, Hongwu, Wang, Wen, Ma, Yanhe, Liu, Yongjun, Li, Yin, Jiang, Huifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435721/
https://www.ncbi.nlm.nih.gov/pubmed/30914637
http://dx.doi.org/10.1038/s41467-019-09095-z

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