Cargando…

Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry

BACKGROUND: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. METHODS: Of the 23,254 new lung...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ho Cheol, Jung, Chi Young, Cho, Deog Gon, Jeon, Jae Hyun, Lee, Jeong Eun, Ahn, Jin Seok, Kim, Seung Joon, Kim, Yeongdae, Kim, Young-Chul, Kim, Jung-Eun, Lee, Boram, Won, Young-Joo, Choi, Chang-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435924/
https://www.ncbi.nlm.nih.gov/pubmed/29926550
http://dx.doi.org/10.4046/trd.2017.0128
_version_ 1783406726382354432
author Kim, Ho Cheol
Jung, Chi Young
Cho, Deog Gon
Jeon, Jae Hyun
Lee, Jeong Eun
Ahn, Jin Seok
Kim, Seung Joon
Kim, Yeongdae
Kim, Young-Chul
Kim, Jung-Eun
Lee, Boram
Won, Young-Joo
Choi, Chang-Min
author_facet Kim, Ho Cheol
Jung, Chi Young
Cho, Deog Gon
Jeon, Jae Hyun
Lee, Jeong Eun
Ahn, Jin Seok
Kim, Seung Joon
Kim, Yeongdae
Kim, Young-Chul
Kim, Jung-Eun
Lee, Boram
Won, Young-Joo
Choi, Chang-Min
author_sort Kim, Ho Cheol
collection PubMed
description BACKGROUND: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. METHODS: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015. RESULTS: The median age was 69 years (interquartile range, 60–74 years); 65.4% were male and 62.1% were ever-smokers. Cough was the most common initial symptom (33.5%); 13.1% of patients were asymptomatic. While squamous cell carcinoma was the most common subtype in male patients (37.2%), adenocarcinoma was the most frequent histological type in all patients (48.7%) and females (76.3%). The majority of patients received treatment (76.5%), which included surgery, radiation therapy, and chemotherapy. Older age (hazard ratio [HR], 1.037), lower body mass index (HR, 0.904), ever-smoker (HR, 2.003), small cell lung cancer (HR, 1.627), and distant metastasis (HR, 3.990) were independent predictors of mortality. Patients without symptoms (HR, 0.387) and without treatment (HR, 0.364) were associated with a favorable outcome in multivariate Cox analysis. CONCLUSION: Lung cancer in Korea occurs predominantly in elderly patients, with adenocarcinoma being the most frequent subtype. The prognosis was poorer in ever-smokers and older, malnourished, and untreated patients with advanced lung cancer.
format Online
Article
Text
id pubmed-6435924
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Korean Academy of Tuberculosis and Respiratory Diseases
record_format MEDLINE/PubMed
spelling pubmed-64359242019-04-02 Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry Kim, Ho Cheol Jung, Chi Young Cho, Deog Gon Jeon, Jae Hyun Lee, Jeong Eun Ahn, Jin Seok Kim, Seung Joon Kim, Yeongdae Kim, Young-Chul Kim, Jung-Eun Lee, Boram Won, Young-Joo Choi, Chang-Min Tuberc Respir Dis (Seoul) Original Article BACKGROUND: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. METHODS: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015. RESULTS: The median age was 69 years (interquartile range, 60–74 years); 65.4% were male and 62.1% were ever-smokers. Cough was the most common initial symptom (33.5%); 13.1% of patients were asymptomatic. While squamous cell carcinoma was the most common subtype in male patients (37.2%), adenocarcinoma was the most frequent histological type in all patients (48.7%) and females (76.3%). The majority of patients received treatment (76.5%), which included surgery, radiation therapy, and chemotherapy. Older age (hazard ratio [HR], 1.037), lower body mass index (HR, 0.904), ever-smoker (HR, 2.003), small cell lung cancer (HR, 1.627), and distant metastasis (HR, 3.990) were independent predictors of mortality. Patients without symptoms (HR, 0.387) and without treatment (HR, 0.364) were associated with a favorable outcome in multivariate Cox analysis. CONCLUSION: Lung cancer in Korea occurs predominantly in elderly patients, with adenocarcinoma being the most frequent subtype. The prognosis was poorer in ever-smokers and older, malnourished, and untreated patients with advanced lung cancer. The Korean Academy of Tuberculosis and Respiratory Diseases 2019-04 2018-06-19 /pmc/articles/PMC6435924/ /pubmed/29926550 http://dx.doi.org/10.4046/trd.2017.0128 Text en Copyright©2019. The Korean Academy of Tuberculosis and Respiratory Diseases http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Kim, Ho Cheol
Jung, Chi Young
Cho, Deog Gon
Jeon, Jae Hyun
Lee, Jeong Eun
Ahn, Jin Seok
Kim, Seung Joon
Kim, Yeongdae
Kim, Young-Chul
Kim, Jung-Eun
Lee, Boram
Won, Young-Joo
Choi, Chang-Min
Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title_full Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title_fullStr Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title_full_unstemmed Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title_short Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry
title_sort clinical characteristics and prognostic factors of lung cancer in korea: a pilot study of data from the korean nationwide lung cancer registry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435924/
https://www.ncbi.nlm.nih.gov/pubmed/29926550
http://dx.doi.org/10.4046/trd.2017.0128
work_keys_str_mv AT kimhocheol clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT jungchiyoung clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT chodeoggon clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT jeonjaehyun clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT leejeongeun clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT ahnjinseok clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT kimseungjoon clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT kimyeongdae clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT kimyoungchul clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT kimjungeun clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT leeboram clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT wonyoungjoo clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry
AT choichangmin clinicalcharacteristicsandprognosticfactorsoflungcancerinkoreaapilotstudyofdatafromthekoreannationwidelungcancerregistry