Lymphatic Function in Autoimmune Diseases

Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the pathophysiology of rheumatic autoimmune disea...

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Detalles Bibliográficos
Autores principales: Schwartz, Noa, Chalasani, Madhavi Latha S., Li, Thomas M., Feng, Zhonghui, Shipman, William D., Lu, Theresa T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435962/
https://www.ncbi.nlm.nih.gov/pubmed/30949174
http://dx.doi.org/10.3389/fimmu.2019.00519
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author Schwartz, Noa
Chalasani, Madhavi Latha S.
Li, Thomas M.
Feng, Zhonghui
Shipman, William D.
Lu, Theresa T.
author_facet Schwartz, Noa
Chalasani, Madhavi Latha S.
Li, Thomas M.
Feng, Zhonghui
Shipman, William D.
Lu, Theresa T.
author_sort Schwartz, Noa
collection PubMed
description Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the pathophysiology of rheumatic autoimmune diseases. Here we review the current understanding of the role of lymphatics in the autoimmune diseases rheumatoid arthritis, scleroderma, lupus, and dermatomyositis and consider the possibility that manual therapies such as massage and acupuncture may be useful in improving lymphatic function in autoimmune diseases.
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spelling pubmed-64359622019-04-04 Lymphatic Function in Autoimmune Diseases Schwartz, Noa Chalasani, Madhavi Latha S. Li, Thomas M. Feng, Zhonghui Shipman, William D. Lu, Theresa T. Front Immunol Immunology Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the pathophysiology of rheumatic autoimmune diseases. Here we review the current understanding of the role of lymphatics in the autoimmune diseases rheumatoid arthritis, scleroderma, lupus, and dermatomyositis and consider the possibility that manual therapies such as massage and acupuncture may be useful in improving lymphatic function in autoimmune diseases. Frontiers Media S.A. 2019-03-20 /pmc/articles/PMC6435962/ /pubmed/30949174 http://dx.doi.org/10.3389/fimmu.2019.00519 Text en Copyright © 2019 Schwartz, Chalasani, Li, Feng, Shipman and Lu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schwartz, Noa
Chalasani, Madhavi Latha S.
Li, Thomas M.
Feng, Zhonghui
Shipman, William D.
Lu, Theresa T.
Lymphatic Function in Autoimmune Diseases
title Lymphatic Function in Autoimmune Diseases
title_full Lymphatic Function in Autoimmune Diseases
title_fullStr Lymphatic Function in Autoimmune Diseases
title_full_unstemmed Lymphatic Function in Autoimmune Diseases
title_short Lymphatic Function in Autoimmune Diseases
title_sort lymphatic function in autoimmune diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435962/
https://www.ncbi.nlm.nih.gov/pubmed/30949174
http://dx.doi.org/10.3389/fimmu.2019.00519
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AT fengzhonghui lymphaticfunctioninautoimmunediseases
AT shipmanwilliamd lymphaticfunctioninautoimmunediseases
AT lutheresat lymphaticfunctioninautoimmunediseases

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