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CD28 (null) CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28 (null)). These highly cytotoxic CD4 T cells were isolated from disease-af...

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Detalles Bibliográficos
Autores principales: Bano, Aalia, Pera, Alejandra, Almoukayed, Ahmad, Clarke, Thomas H.S., Kirmani, Sukaina, Davies, Kevin A., Kern, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436193/
https://www.ncbi.nlm.nih.gov/pubmed/30984377
http://dx.doi.org/10.12688/f1000research.17119.1
Descripción
Sumario:Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28 (null)). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other chronic inflammatory diseases and their numbers appeared to be linked to disease severity. However, we recently demonstrated that the common herpes virus, cytomegalovirus (CMV), not ageing, is the major driver of this subset of cytotoxic T cells. In this review, we discuss how CMV might potentiate and exacerbate autoimmune disease through the expansion of CD28 (null) CD4 T cells.