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GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial

This study is aimed at comparing clinical pregnancy rates (CPRs) in patients who are administered either gonadotropin-releasing hormone agonist (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study wa...

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Autores principales: Le, Minh Tam, Nguyen, Dac Nguyen, Zolton, Jessica, Nguyen, Vu Quoc Huy, Truong, Quang Vinh, Cao, Ngoc Thanh, Decherney, Alan, Hill, Micah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436329/
https://www.ncbi.nlm.nih.gov/pubmed/31001335
http://dx.doi.org/10.1155/2019/2487067
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author Le, Minh Tam
Nguyen, Dac Nguyen
Zolton, Jessica
Nguyen, Vu Quoc Huy
Truong, Quang Vinh
Cao, Ngoc Thanh
Decherney, Alan
Hill, Micah J.
author_facet Le, Minh Tam
Nguyen, Dac Nguyen
Zolton, Jessica
Nguyen, Vu Quoc Huy
Truong, Quang Vinh
Cao, Ngoc Thanh
Decherney, Alan
Hill, Micah J.
author_sort Le, Minh Tam
collection PubMed
description This study is aimed at comparing clinical pregnancy rates (CPRs) in patients who are administered either gonadotropin-releasing hormone agonist (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. A total of 197 infertile women were randomly assigned to receive either GnRHa trigger (n = 98 cycles) or hCG trigger (n = 99 cycles) for ovulation trigger. Patients returned for ultrasound monitoring 24 hours after IUI to confirm ovulation. A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity. There was no difference in ovulation rates in either group receiving GnRHa or hCG trigger for ovulation. Biochemical and CPR were higher in patients who received hCG (28.3% and 23.2%) versus GnRHa (14.3% and 13.3%) (p = 0.023, OR 0.42, 95%CI = 0.21 − 0.86 and p = 0.096, OR 0.51, 95%CI = 0.24 − 1.07, respectively). After adjusting for body mass index (BMI) and infertility duration, there was no difference in CPR between the two groups (OR 0.58, 95% CI 0.27-1.25, p = 0.163). In conclusion, the use of the GnRHa to trigger ovulation in patients undergoing ovulation induction may be considered in patients treated with IUI.
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spelling pubmed-64363292019-04-18 GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial Le, Minh Tam Nguyen, Dac Nguyen Zolton, Jessica Nguyen, Vu Quoc Huy Truong, Quang Vinh Cao, Ngoc Thanh Decherney, Alan Hill, Micah J. Int J Endocrinol Clinical Study This study is aimed at comparing clinical pregnancy rates (CPRs) in patients who are administered either gonadotropin-releasing hormone agonist (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. A total of 197 infertile women were randomly assigned to receive either GnRHa trigger (n = 98 cycles) or hCG trigger (n = 99 cycles) for ovulation trigger. Patients returned for ultrasound monitoring 24 hours after IUI to confirm ovulation. A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity. There was no difference in ovulation rates in either group receiving GnRHa or hCG trigger for ovulation. Biochemical and CPR were higher in patients who received hCG (28.3% and 23.2%) versus GnRHa (14.3% and 13.3%) (p = 0.023, OR 0.42, 95%CI = 0.21 − 0.86 and p = 0.096, OR 0.51, 95%CI = 0.24 − 1.07, respectively). After adjusting for body mass index (BMI) and infertility duration, there was no difference in CPR between the two groups (OR 0.58, 95% CI 0.27-1.25, p = 0.163). In conclusion, the use of the GnRHa to trigger ovulation in patients undergoing ovulation induction may be considered in patients treated with IUI. Hindawi 2019-03-13 /pmc/articles/PMC6436329/ /pubmed/31001335 http://dx.doi.org/10.1155/2019/2487067 Text en Copyright © 2019 Minh Tam Le et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Le, Minh Tam
Nguyen, Dac Nguyen
Zolton, Jessica
Nguyen, Vu Quoc Huy
Truong, Quang Vinh
Cao, Ngoc Thanh
Decherney, Alan
Hill, Micah J.
GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title_full GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title_fullStr GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title_full_unstemmed GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title_short GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial
title_sort gnrh agonist versus hcg trigger in ovulation induction with intrauterine insemination: a randomized controlled trial
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436329/
https://www.ncbi.nlm.nih.gov/pubmed/31001335
http://dx.doi.org/10.1155/2019/2487067
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