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Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption

A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO(...

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Detalles Bibliográficos
Autores principales: Li, Jinhua, Jiang, Meng, Zhou, Huaijuan, Jin, Ping, Cheung, Kenneth M. C., Chu, Paul K., Yeung, Kelvin W. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436600/
https://www.ncbi.nlm.nih.gov/pubmed/31565366
http://dx.doi.org/10.1002/gch2.201800058
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author Li, Jinhua
Jiang, Meng
Zhou, Huaijuan
Jin, Ping
Cheung, Kenneth M. C.
Chu, Paul K.
Yeung, Kelvin W. K.
author_facet Li, Jinhua
Jiang, Meng
Zhou, Huaijuan
Jin, Ping
Cheung, Kenneth M. C.
Chu, Paul K.
Yeung, Kelvin W. K.
author_sort Li, Jinhua
collection PubMed
description A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO(2)) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor‐growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO(2) nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor‐cell‐inhibited biomaterial surface, which is modulated by the mechanism of mitochondria‐targeting tumor cell death.
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spelling pubmed-64366002019-09-27 Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption Li, Jinhua Jiang, Meng Zhou, Huaijuan Jin, Ping Cheung, Kenneth M. C. Chu, Paul K. Yeung, Kelvin W. K. Glob Chall Full Papers A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO(2)) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor‐growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO(2) nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor‐cell‐inhibited biomaterial surface, which is modulated by the mechanism of mitochondria‐targeting tumor cell death. John Wiley and Sons Inc. 2018-12-03 /pmc/articles/PMC6436600/ /pubmed/31565366 http://dx.doi.org/10.1002/gch2.201800058 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Li, Jinhua
Jiang, Meng
Zhou, Huaijuan
Jin, Ping
Cheung, Kenneth M. C.
Chu, Paul K.
Yeung, Kelvin W. K.
Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title_full Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title_fullStr Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title_full_unstemmed Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title_short Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
title_sort vanadium dioxide nanocoating induces tumor cell death through mitochondrial electron transport chain interruption
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436600/
https://www.ncbi.nlm.nih.gov/pubmed/31565366
http://dx.doi.org/10.1002/gch2.201800058
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