Cargando…

Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials

BACKGROUND: Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. METHODS: A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernstein, David I., Cardin, Rhonda D., Pullum, Derek A., Bravo, Fernando J., Kousoulas, Konstantin G., Dixon, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436793/ https://www.ncbi.nlm.nih.gov/pubmed/30917165 http://dx.doi.org/10.1371/journal.pone.0213401

Ejemplares similares

The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model
por: Bernstein, David I., et al.
Publicado: (2020)

Successful application of prime and pull strategy for a therapeutic HSV vaccine
por: Bernstein, David I., et al.
Publicado: (2019)

Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs
por: Brans, Richard, et al.
Publicado: (2010)

The Effect of Herpes Simplex Virus-Type-1 (HSV-1) Oncolytic Immunotherapy on the Tumor Microenvironment
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2021)

Immunisation Using Novel DNA Vaccine Encoding Virus Membrane Fusion Complex and Chemokine Genes Shows High Protection from HSV-2
por: Gompels, Ursula A., et al.
Publicado: (2022)

Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response
por: Holub, Michal, et al.
Publicado: (2020)

Effect of Genital Herpes on Cervicovaginal HIV Shedding in Women Co-Infected with HIV AND HSV-2 in Tanzania
por: Todd, Jim, et al.
Publicado: (2013)

A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs
por: Zhang, Pengwei, et al.
Publicado: (2014)

Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection
por: Egan, Kevin, et al.
Publicado: (2020)

Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice
por: Israyelyan, Anna, et al.
Publicado: (2008)

A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model
por: Awasthi, Sita, et al.
Publicado: (2017)

Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion
por: Govender, Yashini, et al.
Publicado: (2023)

Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract
por: Posavad, Christine M., et al.
Publicado: (2017)

Herpes genital .
por: Rivera Gómez, Jesús
Publicado: (1996)

Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
por: Naidu, Shan K., et al.
Publicado: (2020)

Persistence of mucosal T cell responses to herpes simplex virus type 2 (HSV-2) in the female genital tract
por: Posavad, Christine M., et al.
Publicado: (2014)

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection
por: Egan, Kevin P., et al.
Publicado: (2020)

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine
por: Hook, Lauren M., et al.
Publicado: (2022)

Herpes genital : revisión bibliográfica
por: Macedo Díaz, Adriana
Publicado: (1999)

Herpes genital : revisión bibliográfica
por: Gómez González, Omar
Publicado: (2003)

Genital and neonatal herpes /
Publicado: (1996)

Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 (HSV-2) in Guinea Pigs
por: Joyce, Jonathan D., et al.
Publicado: (2021)

Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
por: Iyer, Arun V, et al.
Publicado: (2013)

The population impact of herpes simplex virus type 2 (HSV-2) vaccination on the incidence of HSV-2, HIV and genital ulcer disease in South Africa: a mathematical modelling study
por: Stone, Jack, et al.
Publicado: (2023)

Neonatal Genital HSV-1 After Jewish Circumcision
por: Tzvi-Behr, Shimrit, et al.
Publicado: (2015)

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs
Publicado: (1995)

Virus-Specific Immune Memory at Peripheral Sites of Herpes Simplex Virus Type 2 (HSV-2) Infection in Guinea Pigs
por: Xia, Jingya, et al.
Publicado: (2014)

An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model
por: Wan, Mingming, et al.
Publicado: (2023)

Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes
por: Katsumata, Kiyomitsu, et al.
Publicado: (2011)

A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics
por: Pieknik, Julianna R., et al.
Publicado: (2018)

Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs
por: Awasthi, Sita, et al.
Publicado: (2023)

Pan-HSV-2 IgG Antibody in Vaccinated Mice and Guinea Pigs Correlates with Protection against Herpes Simplex Virus 2
por: Halford, William P., et al.
Publicado: (2013)

Utility of a Recombinant HSV-1 Vaccine Vector for Personalized Cancer Vaccines
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2022)

Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial
por: Bernstein, David I., et al.
Publicado: (2017)

1333 Therapeutic HSV-2 vaccine (GEN003) results in durable reduction in genital lesions at 1 year
por: Wald, Anna, et al.
Publicado: (2014)

Microbial Diversity of Genital Ulcers of HSV-2 Seropositive Women
por: Mehta, Supriya D., et al.
Publicado: (2017)

Immunoregulatory Functions of Interferons During Genital HSV-2 Infection
por: Feng, Emily, et al.
Publicado: (2021)

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs
por: Persson, Josefine, et al.
Publicado: (2016)

Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
por: Morrow, Rhoda Ashley, et al.
Publicado: (2005)

A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains
por: Stanfield, Brent A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_om3v5185id3vu9bmq7b14lekv6