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Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity
BACKGROUND. The human bone marrow (BM) niche contains a population of mesenchymal stromal cells (MSCs) that provide physical support and regulate hematopoietic stem cell (HSC) homeostasis. β-Thalassemia (BT) is a hereditary disorder characterized by altered hemoglobin beta-chain synthesis amenable t...
Autores principales: | Crippa, Stefania, Rossella, Valeria, Aprile, Annamaria, Silvestri, Laura, Rivis, Silvia, Scaramuzza, Samantha, Pirroni, Stefania, Avanzini, Maria Antonietta, Basso-Ricci, Luca, Hernandez, Raisa Jofra, Zecca, Marco, Marktel, Sarah, Ciceri, Fabio, Aiuti, Alessandro, Ferrari, Giuliana, Bernardo, Maria Ester |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436882/ https://www.ncbi.nlm.nih.gov/pubmed/30830876 http://dx.doi.org/10.1172/JCI123191 |
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