An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT, is bactericidal unless neutralized by its antitoxin MbcA...

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Detalles Bibliográficos
Autores principales: Freire, Diana Mendes, Gutierrez, Claude, Garza-Garcia, Acely, Grabowska, Anna D., Sala, Ambre J., Ariyachaokun, Kanchiyaphat, Panikova, Terezie, Beckham, Katherine S.H., Colom, André, Pogenberg, Vivian, Cianci, Michele, Tuukkanen, Anne, Boudehen, Yves-Marie, Peixoto, Antonio, Botella, Laure, Svergun, Dmitri I., Schnappinger, Dirk, Schneider, Thomas R., Genevaux, Pierre, de Carvalho, Luiz Pedro Sorio, Wilmanns, Matthias, Parret, Annabel H.A., Neyrolles, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436930/
https://www.ncbi.nlm.nih.gov/pubmed/30792174
http://dx.doi.org/10.1016/j.molcel.2019.01.028

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