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An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases
Myelin is made by highly specialized glial cells and enables fast axonal impulse propagation. Recent studies show that oligodendrocytes in the central nervous system are, in addition to myelination, required for the integrity and survival of axons, independent of the presence or absence of myelin it...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Les Laboratoires Servier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436955/ https://www.ncbi.nlm.nih.gov/pubmed/30936768 |
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author | Mot, Alexandra I. Depp, Constanze Nave, Klaus-Armin |
author_facet | Mot, Alexandra I. Depp, Constanze Nave, Klaus-Armin |
author_sort | Mot, Alexandra I. |
collection | PubMed |
description | Myelin is made by highly specialized glial cells and enables fast axonal impulse propagation. Recent studies show that oligodendrocytes in the central nervous system are, in addition to myelination, required for the integrity and survival of axons, independent of the presence or absence of myelin itself. The underlying mechanism of this support is given by glycolytic oligodendrocytes which provide axons with energy-rich metabolites. These findings represent a paradigm shift for the physiological function of axon-associated glia, and open the intriguing possibility that oligodendrocytes are important contributors to neurodegenerative diseases in which myelinated axons are lost, such as in Alzheimer disease, amyotrophic lateral sclerosis, and multiple system atrophy. Understanding the role of axon-oligodendrocyte coupling in neurodegenerative diseases may pave the way for the development of metabolism-based therapeutic approaches. |
format | Online Article Text |
id | pubmed-6436955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64369552019-04-01 An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases Mot, Alexandra I. Depp, Constanze Nave, Klaus-Armin Dialogues Clin Neurosci Translational Research Myelin is made by highly specialized glial cells and enables fast axonal impulse propagation. Recent studies show that oligodendrocytes in the central nervous system are, in addition to myelination, required for the integrity and survival of axons, independent of the presence or absence of myelin itself. The underlying mechanism of this support is given by glycolytic oligodendrocytes which provide axons with energy-rich metabolites. These findings represent a paradigm shift for the physiological function of axon-associated glia, and open the intriguing possibility that oligodendrocytes are important contributors to neurodegenerative diseases in which myelinated axons are lost, such as in Alzheimer disease, amyotrophic lateral sclerosis, and multiple system atrophy. Understanding the role of axon-oligodendrocyte coupling in neurodegenerative diseases may pave the way for the development of metabolism-based therapeutic approaches. Les Laboratoires Servier 2018-12 /pmc/articles/PMC6436955/ /pubmed/30936768 Text en Copyright: © 2018 AICH - Servier Group. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Translational Research Mot, Alexandra I. Depp, Constanze Nave, Klaus-Armin An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title | An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title_full | An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title_fullStr | An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title_full_unstemmed | An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title_short | An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
title_sort | emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases |
topic | Translational Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436955/ https://www.ncbi.nlm.nih.gov/pubmed/30936768 |
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