Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits

Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hi...

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Detalles Bibliográficos
Autores principales: Katrancha, Sara Marie, Shaw, Juliana E., Zhao, Amy Y., Myers, Samuel A., Cocco, Alexandra R., Jeng, Amanda T., Zhu, Minsheng, Pittenger, Christopher, Greer, Charles A., Carr, Steven A., Xiao, Xiao, Koleske, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436967/
https://www.ncbi.nlm.nih.gov/pubmed/30840899
http://dx.doi.org/10.1016/j.celrep.2019.02.022

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