Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium tuberculosis in vitro and in vivo. However, its mechanism of action is unknown. IPA is the deamination product of tryptophan (Trp) and thus a close structural analog of this essential aromatic amino acid. De...

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Detalles Bibliográficos
Autores principales: Negatu, Dereje Abate, Yamada, Yoshiyuki, Xi, Yu, Go, Mei Lin, Zimmerman, Matthew, Ganapathy, Uday, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437058/
https://www.ncbi.nlm.nih.gov/pubmed/30914514
http://dx.doi.org/10.1128/mBio.02781-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437058/
https://www.ncbi.nlm.nih.gov/pubmed/30914514
http://dx.doi.org/10.1128/mBio.02781-18

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