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Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records
The present work explores the diagnostic performance for depression of neural network classifiers analyzing the sound structures of laughter as registered from clinical patients and healthy controls. The main methodological novelty of this work is that simple sound variables of laughter are used as...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437104/ https://www.ncbi.nlm.nih.gov/pubmed/30949025 http://dx.doi.org/10.3389/fnins.2019.00267 |
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author | Navarro, Jorge Fernández Rosell, Mercedes Castellanos, Angel del Moral, Raquel Lahoz-Beltra, Rafael Marijuán, Pedro C. |
author_facet | Navarro, Jorge Fernández Rosell, Mercedes Castellanos, Angel del Moral, Raquel Lahoz-Beltra, Rafael Marijuán, Pedro C. |
author_sort | Navarro, Jorge |
collection | PubMed |
description | The present work explores the diagnostic performance for depression of neural network classifiers analyzing the sound structures of laughter as registered from clinical patients and healthy controls. The main methodological novelty of this work is that simple sound variables of laughter are used as inputs, instead of electrophysiological signals or local field potentials (LFPs) or spoken language utterances, which are the usual protocols up-to-date. In the present study, involving 934 laughs from 30 patients and 20 controls, four different neural networks models were tested for sensitivity analysis, and were additionally trained for depression detection. Some elementary sound variables were extracted from the records: timing, fundamental frequency mean, first three formants, average power, and the Shannon-Wiener entropy. In the results obtained, two of the neural networks show a diagnostic discrimination capability of 93.02 and 91.15% respectively, while the third and fourth ones have an 87.96 and 82.40% percentage of success. Remarkably, entropy turns out to be a fundamental variable to distinguish between patients and controls, and this is a significant factor which becomes essential to understand the deep neurocognitive relationships between laughter and depression. In biomedical terms, our neural network classifier-based neuroprosthesis opens up the possibility of applying the same methodology to other mental-health and neuropsychiatric pathologies. Indeed, exploring the application of laughter in the early detection and prognosis of Alzheimer and Parkinson would represent an enticing possibility, both from the biomedical and the computational points of view. |
format | Online Article Text |
id | pubmed-6437104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64371042019-04-04 Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records Navarro, Jorge Fernández Rosell, Mercedes Castellanos, Angel del Moral, Raquel Lahoz-Beltra, Rafael Marijuán, Pedro C. Front Neurosci Neuroscience The present work explores the diagnostic performance for depression of neural network classifiers analyzing the sound structures of laughter as registered from clinical patients and healthy controls. The main methodological novelty of this work is that simple sound variables of laughter are used as inputs, instead of electrophysiological signals or local field potentials (LFPs) or spoken language utterances, which are the usual protocols up-to-date. In the present study, involving 934 laughs from 30 patients and 20 controls, four different neural networks models were tested for sensitivity analysis, and were additionally trained for depression detection. Some elementary sound variables were extracted from the records: timing, fundamental frequency mean, first three formants, average power, and the Shannon-Wiener entropy. In the results obtained, two of the neural networks show a diagnostic discrimination capability of 93.02 and 91.15% respectively, while the third and fourth ones have an 87.96 and 82.40% percentage of success. Remarkably, entropy turns out to be a fundamental variable to distinguish between patients and controls, and this is a significant factor which becomes essential to understand the deep neurocognitive relationships between laughter and depression. In biomedical terms, our neural network classifier-based neuroprosthesis opens up the possibility of applying the same methodology to other mental-health and neuropsychiatric pathologies. Indeed, exploring the application of laughter in the early detection and prognosis of Alzheimer and Parkinson would represent an enticing possibility, both from the biomedical and the computational points of view. Frontiers Media S.A. 2019-03-21 /pmc/articles/PMC6437104/ /pubmed/30949025 http://dx.doi.org/10.3389/fnins.2019.00267 Text en Copyright © 2019 Navarro, Fernández Rosell, Castellanos, del Moral, Lahoz-Beltra and Marijuán. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Navarro, Jorge Fernández Rosell, Mercedes Castellanos, Angel del Moral, Raquel Lahoz-Beltra, Rafael Marijuán, Pedro C. Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title | Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title_full | Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title_fullStr | Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title_full_unstemmed | Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title_short | Plausibility of a Neural Network Classifier-Based Neuroprosthesis for Depression Detection via Laughter Records |
title_sort | plausibility of a neural network classifier-based neuroprosthesis for depression detection via laughter records |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437104/ https://www.ncbi.nlm.nih.gov/pubmed/30949025 http://dx.doi.org/10.3389/fnins.2019.00267 |
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