A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation

We demonstrate a 4.8-μV(rms) noise microelectrode array (MEA) based on the complementary-metal-oxide-semiconductor active-pixel-sensors readout technique with disaggregated differential amplifier implementation. The circuit elements of the differential amplifier are divided into a readout pixel, a r...

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Detalles Bibliográficos
Autores principales: Ogi, Jun, Kato, Yuri, Nakashima, Yusaku, Ikeda, Kenji, Jingu, Motoko, Matoba, Yoshihisa, Kimizuka, Naohiko, Yamane, Chigusa, Maehara, Masataka, Kishimoto, Takuya, Hashimoto, Shigeki, Matsui, Eriko, Oike, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437115/
https://www.ncbi.nlm.nih.gov/pubmed/30949022
http://dx.doi.org/10.3389/fnins.2019.00234
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author Ogi, Jun
Kato, Yuri
Nakashima, Yusaku
Ikeda, Kenji
Jingu, Motoko
Matoba, Yoshihisa
Kimizuka, Naohiko
Yamane, Chigusa
Maehara, Masataka
Kishimoto, Takuya
Hashimoto, Shigeki
Matsui, Eriko
Oike, Yusuke
author_facet Ogi, Jun
Kato, Yuri
Nakashima, Yusaku
Ikeda, Kenji
Jingu, Motoko
Matoba, Yoshihisa
Kimizuka, Naohiko
Yamane, Chigusa
Maehara, Masataka
Kishimoto, Takuya
Hashimoto, Shigeki
Matsui, Eriko
Oike, Yusuke
author_sort Ogi, Jun
collection PubMed
description We demonstrate a 4.8-μV(rms) noise microelectrode array (MEA) based on the complementary-metal-oxide-semiconductor active-pixel-sensors readout technique with disaggregated differential amplifier implementation. The circuit elements of the differential amplifier are divided into a readout pixel, a reference pixel, and a column circuit. This disaggregation contributes to the small area of the readout pixel, which is less than 81 μm(2). We observed neuron signals around 100 μV with 432 electrodes in a fabricated prototype chip. The implementation has technological feasibility of up to 12-μm-pitch electrode density and 6,912 readout channels for high-spatial resolution mapping of neuron network activity.
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spelling pubmed-64371152019-04-04 A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation Ogi, Jun Kato, Yuri Nakashima, Yusaku Ikeda, Kenji Jingu, Motoko Matoba, Yoshihisa Kimizuka, Naohiko Yamane, Chigusa Maehara, Masataka Kishimoto, Takuya Hashimoto, Shigeki Matsui, Eriko Oike, Yusuke Front Neurosci Neuroscience We demonstrate a 4.8-μV(rms) noise microelectrode array (MEA) based on the complementary-metal-oxide-semiconductor active-pixel-sensors readout technique with disaggregated differential amplifier implementation. The circuit elements of the differential amplifier are divided into a readout pixel, a reference pixel, and a column circuit. This disaggregation contributes to the small area of the readout pixel, which is less than 81 μm(2). We observed neuron signals around 100 μV with 432 electrodes in a fabricated prototype chip. The implementation has technological feasibility of up to 12-μm-pitch electrode density and 6,912 readout channels for high-spatial resolution mapping of neuron network activity. Frontiers Media S.A. 2019-03-21 /pmc/articles/PMC6437115/ /pubmed/30949022 http://dx.doi.org/10.3389/fnins.2019.00234 Text en Copyright © 2019 Ogi, Kato, Nakashima, Ikeda, Jingu, Matoba, Kimizuka, Yamane, Maehara, Kishimoto, Hashimoto, Matsui and Oike. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ogi, Jun
Kato, Yuri
Nakashima, Yusaku
Ikeda, Kenji
Jingu, Motoko
Matoba, Yoshihisa
Kimizuka, Naohiko
Yamane, Chigusa
Maehara, Masataka
Kishimoto, Takuya
Hashimoto, Shigeki
Matsui, Eriko
Oike, Yusuke
A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title_full A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title_fullStr A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title_full_unstemmed A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title_short A 4.8-μV(rms)-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation
title_sort 4.8-μv(rms)-noise cmos-microelectrode array with density-scalable active readout pixels via disaggregated differential amplifier implementation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437115/
https://www.ncbi.nlm.nih.gov/pubmed/30949022
http://dx.doi.org/10.3389/fnins.2019.00234
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