Cargando…

Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study

Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia–reperfusion injury (IRI). Propofol, an anesthetic, is known to...

Descripción completa

Detalles Bibliográficos
Autores principales: Roh, Go Un, Song, Young, Park, Junbeom, Ki, Yu Min, Han, Dong Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437140/
https://www.ncbi.nlm.nih.gov/pubmed/30918320
http://dx.doi.org/10.1038/s41598-019-41708-x
_version_ 1783406901708455936
author Roh, Go Un
Song, Young
Park, Junbeom
Ki, Yu Min
Han, Dong Woo
author_facet Roh, Go Un
Song, Young
Park, Junbeom
Ki, Yu Min
Han, Dong Woo
author_sort Roh, Go Un
collection PubMed
description Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia–reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflammatory and antioxidant properties. In the present study, we compared the effects of propofol with those of desflurane on inflammation and IRI during RALRP via measurements of different biomarkers and evaluation of perioperative renal function. Fifty patients were randomized to receive either desflurane (n = 25) or propofol (n = 25) with remifentanil during RALRP. Serum levels of interleukin (IL)-6 (IL-6), tumor necrosis factor alpha, C-reactive protein, and nitric oxide were measured 10 min after anesthesia induction (T1), 100 min after carbon dioxide (CO(2)) insufflation (T2), and 10 min after CO(2) deflation (T3). Perioperative urine outputs and the serum creatinine level at 24 h after surgery were also recorded. We found that IL-6 levels at T2 and T3 were higher than those at T1 in both groups, although the increases were significant attenuated only in the propofol group. The other parameters showed no differences among the three time points in both groups. The intraoperative urine output was significantly higher in the propofol group than in the desflurane group, while the creatinine level showed no significant changes in either group. Our findings suggest that propofol can not only attenuate the inflammatory response during and after pneumoperitoneum in patients undergoing RALRP but also prevent oliguria during pneumoperitoneum.
format Online
Article
Text
id pubmed-6437140
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-64371402019-04-03 Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study Roh, Go Un Song, Young Park, Junbeom Ki, Yu Min Han, Dong Woo Sci Rep Article Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia–reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflammatory and antioxidant properties. In the present study, we compared the effects of propofol with those of desflurane on inflammation and IRI during RALRP via measurements of different biomarkers and evaluation of perioperative renal function. Fifty patients were randomized to receive either desflurane (n = 25) or propofol (n = 25) with remifentanil during RALRP. Serum levels of interleukin (IL)-6 (IL-6), tumor necrosis factor alpha, C-reactive protein, and nitric oxide were measured 10 min after anesthesia induction (T1), 100 min after carbon dioxide (CO(2)) insufflation (T2), and 10 min after CO(2) deflation (T3). Perioperative urine outputs and the serum creatinine level at 24 h after surgery were also recorded. We found that IL-6 levels at T2 and T3 were higher than those at T1 in both groups, although the increases were significant attenuated only in the propofol group. The other parameters showed no differences among the three time points in both groups. The intraoperative urine output was significantly higher in the propofol group than in the desflurane group, while the creatinine level showed no significant changes in either group. Our findings suggest that propofol can not only attenuate the inflammatory response during and after pneumoperitoneum in patients undergoing RALRP but also prevent oliguria during pneumoperitoneum. Nature Publishing Group UK 2019-03-27 /pmc/articles/PMC6437140/ /pubmed/30918320 http://dx.doi.org/10.1038/s41598-019-41708-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Roh, Go Un
Song, Young
Park, Junbeom
Ki, Yu Min
Han, Dong Woo
Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title_full Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title_fullStr Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title_full_unstemmed Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title_short Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
title_sort effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437140/
https://www.ncbi.nlm.nih.gov/pubmed/30918320
http://dx.doi.org/10.1038/s41598-019-41708-x
work_keys_str_mv AT rohgoun effectsofpropofolontheinflammatoryresponseduringrobotassistedlaparoscopicradicalprostatectomyaprospectiverandomizedcontrolledstudy
AT songyoung effectsofpropofolontheinflammatoryresponseduringrobotassistedlaparoscopicradicalprostatectomyaprospectiverandomizedcontrolledstudy
AT parkjunbeom effectsofpropofolontheinflammatoryresponseduringrobotassistedlaparoscopicradicalprostatectomyaprospectiverandomizedcontrolledstudy
AT kiyumin effectsofpropofolontheinflammatoryresponseduringrobotassistedlaparoscopicradicalprostatectomyaprospectiverandomizedcontrolledstudy
AT handongwoo effectsofpropofolontheinflammatoryresponseduringrobotassistedlaparoscopicradicalprostatectomyaprospectiverandomizedcontrolledstudy