Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate...

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Detalles Bibliográficos
Autores principales: Zeng, Yanni, Amador, Carmen, Xia, Charley, Marioni, Riccardo, Sproul, Duncan, Walker, Rosie M., Morris, Stewart W., Bretherick, Andrew, Canela-Xandri, Oriol, Boutin, Thibaud S., Clark, David W., Campbell, Archie, Rawlik, Konrad, Hayward, Caroline, Nagy, Reka, Tenesa, Albert, Porteous, David J., Wilson, James F., Deary, Ian J., Evans, Kathryn L., McIntosh, Andrew M., Navarro, Pau, Haley, Chris S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437195/
https://www.ncbi.nlm.nih.gov/pubmed/30918249
http://dx.doi.org/10.1038/s41467-019-09301-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437195/
https://www.ncbi.nlm.nih.gov/pubmed/30918249
http://dx.doi.org/10.1038/s41467-019-09301-y

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