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A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China

The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We utilized data from a large population-based survey to examine the association between folic acid supplementation and birth defects in Northwestern China. A total of 29,204 women wi...

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Autores principales: Qu, Pengfei, Li, Shanshan, Liu, Danmeng, Lei, Fangliang, Zeng, Lingxia, Wang, Duolao, Yan, Hong, Shi, Wenhao, Shi, Juanzi, Dang, Shaonong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437303/
https://www.ncbi.nlm.nih.gov/pubmed/30918271
http://dx.doi.org/10.1038/s41598-019-41584-5
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author Qu, Pengfei
Li, Shanshan
Liu, Danmeng
Lei, Fangliang
Zeng, Lingxia
Wang, Duolao
Yan, Hong
Shi, Wenhao
Shi, Juanzi
Dang, Shaonong
author_facet Qu, Pengfei
Li, Shanshan
Liu, Danmeng
Lei, Fangliang
Zeng, Lingxia
Wang, Duolao
Yan, Hong
Shi, Wenhao
Shi, Juanzi
Dang, Shaonong
author_sort Qu, Pengfei
collection PubMed
description The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We utilized data from a large population-based survey to examine the association between folic acid supplementation and birth defects in Northwestern China. A total of 29,204 women with infants born between 2010 and 2013 were surveyed in Shaanxi province, Northwestern China, using a stratified multistage sampling method. Propensity scores were used to match 9,293 women with optimal folic acid supplementation with 9,293 women with nonoptimal folic acid supplementation, and the effects of optimal folic acid supplementation on birth defects were assessed by a conditional logistic regression model. After propensity score matching, the overall birth defect rate, cardiovascular system defect rate and nervous system defect rate for the women with optimal folic acid supplementation were lower than those for the women with nonoptimal folic acid supplementation (overall birth defects: OR = 0.71, 95% CI = 0.57–0.89, P = 0.003; cardiovascular system defects: OR = 0.65, 95% CI = 0.44–0.96, P = 0.032; nervous system defects: OR = 0.13, 95% CI = 0.02–0.99, P = 0.049). Optimal folic acid supplementation was associated with a decreased prevalence of birth defects, especially in the cardiovascular system and nervous system. Our findings have important implications for birth defect intervention with folic acid supplementation for countries with a high prevalence of birth defects, such as China.
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spelling pubmed-64373032019-04-03 A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China Qu, Pengfei Li, Shanshan Liu, Danmeng Lei, Fangliang Zeng, Lingxia Wang, Duolao Yan, Hong Shi, Wenhao Shi, Juanzi Dang, Shaonong Sci Rep Article The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We utilized data from a large population-based survey to examine the association between folic acid supplementation and birth defects in Northwestern China. A total of 29,204 women with infants born between 2010 and 2013 were surveyed in Shaanxi province, Northwestern China, using a stratified multistage sampling method. Propensity scores were used to match 9,293 women with optimal folic acid supplementation with 9,293 women with nonoptimal folic acid supplementation, and the effects of optimal folic acid supplementation on birth defects were assessed by a conditional logistic regression model. After propensity score matching, the overall birth defect rate, cardiovascular system defect rate and nervous system defect rate for the women with optimal folic acid supplementation were lower than those for the women with nonoptimal folic acid supplementation (overall birth defects: OR = 0.71, 95% CI = 0.57–0.89, P = 0.003; cardiovascular system defects: OR = 0.65, 95% CI = 0.44–0.96, P = 0.032; nervous system defects: OR = 0.13, 95% CI = 0.02–0.99, P = 0.049). Optimal folic acid supplementation was associated with a decreased prevalence of birth defects, especially in the cardiovascular system and nervous system. Our findings have important implications for birth defect intervention with folic acid supplementation for countries with a high prevalence of birth defects, such as China. Nature Publishing Group UK 2019-03-27 /pmc/articles/PMC6437303/ /pubmed/30918271 http://dx.doi.org/10.1038/s41598-019-41584-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Qu, Pengfei
Li, Shanshan
Liu, Danmeng
Lei, Fangliang
Zeng, Lingxia
Wang, Duolao
Yan, Hong
Shi, Wenhao
Shi, Juanzi
Dang, Shaonong
A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title_full A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title_fullStr A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title_full_unstemmed A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title_short A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China
title_sort propensity-matched study of the association between optimal folic acid supplementation and birth defects in shaanxi province, northwestern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437303/
https://www.ncbi.nlm.nih.gov/pubmed/30918271
http://dx.doi.org/10.1038/s41598-019-41584-5
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