Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review

Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest...

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Detalles Bibliográficos
Autores principales: Milonas, Dimitrios, Didangelos, Triantafyllos, Hatzitolios, Apostolos I., Tziomalos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437305/
https://www.ncbi.nlm.nih.gov/pubmed/30725400
http://dx.doi.org/10.1007/s13300-019-0580-z
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author Milonas, Dimitrios
Didangelos, Triantafyllos
Hatzitolios, Apostolos I.
Tziomalos, Konstantinos
author_facet Milonas, Dimitrios
Didangelos, Triantafyllos
Hatzitolios, Apostolos I.
Tziomalos, Konstantinos
author_sort Milonas, Dimitrios
collection PubMed
description Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. It appears that these agents exert neuroprotective actions that might both reduce infarct size and promote recovery. The present review summarizes the evidence on the potential role of incretin-based antihyperglycemic agents in the management of acute ischemic stroke.
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spelling pubmed-64373052019-04-15 Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review Milonas, Dimitrios Didangelos, Triantafyllos Hatzitolios, Apostolos I. Tziomalos, Konstantinos Diabetes Ther Review Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. It appears that these agents exert neuroprotective actions that might both reduce infarct size and promote recovery. The present review summarizes the evidence on the potential role of incretin-based antihyperglycemic agents in the management of acute ischemic stroke. Springer Healthcare 2019-02-06 2019-04 /pmc/articles/PMC6437305/ /pubmed/30725400 http://dx.doi.org/10.1007/s13300-019-0580-z Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Milonas, Dimitrios
Didangelos, Triantafyllos
Hatzitolios, Apostolos I.
Tziomalos, Konstantinos
Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title_full Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title_fullStr Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title_full_unstemmed Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title_short Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
title_sort incretin-based antihyperglycemic agents for the management of acute ischemic stroke in patients with diabetes mellitus: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437305/
https://www.ncbi.nlm.nih.gov/pubmed/30725400
http://dx.doi.org/10.1007/s13300-019-0580-z
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