Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study

Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors (FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designin...

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Detalles Bibliográficos
Autores principales: Wei, Peng, Liu, Bo, Wang, Ruifeng, Gao, Yinglei, Li, Lanlan, Ma, Yuchi, Qian, Zhiwei, Chen, Yuelei, Cheng, Maosheng, Geng, Meiyu, Shen, Jingkang, Zhao, Dongmei, Ai, Jing, Xiong, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437634/
https://www.ncbi.nlm.nih.gov/pubmed/30972282
http://dx.doi.org/10.1016/j.apsb.2018.12.008

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