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Variability in human plasma volume responses during high‐altitude sojourn
When sea‐level (SL) residents rapidly ascend to high altitude (HA), plasma volume (PV) decreases. A quantitative model for predicting individual %∆PV over the first 7 days at HA has recently been developed from the measurements of %∆PV in 393 HA sojourners. We compared the measured %∆PV with the %∆P...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437695/ https://www.ncbi.nlm.nih.gov/pubmed/30920186 http://dx.doi.org/10.14814/phy2.14051 |
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author | Young, Andrew J. Karl, James P. Berryman, Claire E. Montain, Scott J. Beidleman, Beth A. Pasiakos, Stefan M. |
author_facet | Young, Andrew J. Karl, James P. Berryman, Claire E. Montain, Scott J. Beidleman, Beth A. Pasiakos, Stefan M. |
author_sort | Young, Andrew J. |
collection | PubMed |
description | When sea‐level (SL) residents rapidly ascend to high altitude (HA), plasma volume (PV) decreases. A quantitative model for predicting individual %∆PV over the first 7 days at HA has recently been developed from the measurements of %∆PV in 393 HA sojourners. We compared the measured %∆PV with the %∆PV predicted by the model in 17 SL natives living 21 days at HA (4300 m). Fasting hematocrit (Hct), hemoglobin (Hb) and total circulating protein (TCP) concentrations at SL and on days 2, 7, 13, and 19 at HA were used to calculate %∆TCP and %∆PV. Mean [95%CI] measured %∆PV on HA2, 7, 13 and 19 was −2.5 [−8.2, 3.1], −11.0 [−16.6, −5.5], −11.7 [−15.9, −7.4], and −16.8 [−22.2, −11.3], respectively. %∆PV and %∆TCP were positively correlated (P < 0.001) at HA2, 7, 13, and 19 (r (2) = 0.77, 0.88, 0.78, 0.89, respectively). The model overpredicted mean [95% CI] decrease in %∆PV on HA2 (−12.5 [−13.9, −11.1]) and HA7 (−21.5 [−23.9, −19.1]), accurately predicted the mean decrease on HA13 (−14.3, [−20.0, −8.7]), and predicted a mean increase in %∆PV on HA19 (12.4 [−5.0, 29.8]). On HA2, 7, 13, and 19 only 2, 2, 6, and 1, respectively, of 17 individual measures of %∆PV were within 95% CI for predicted %∆PV. These observations indicate that PV responses to HA are largely oncotically mediated, vary considerably among individuals, and available quantitative models require refinement to predict %∆PV exhibited by individual sojourners. |
format | Online Article Text |
id | pubmed-6437695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64376952019-04-10 Variability in human plasma volume responses during high‐altitude sojourn Young, Andrew J. Karl, James P. Berryman, Claire E. Montain, Scott J. Beidleman, Beth A. Pasiakos, Stefan M. Physiol Rep Original Research When sea‐level (SL) residents rapidly ascend to high altitude (HA), plasma volume (PV) decreases. A quantitative model for predicting individual %∆PV over the first 7 days at HA has recently been developed from the measurements of %∆PV in 393 HA sojourners. We compared the measured %∆PV with the %∆PV predicted by the model in 17 SL natives living 21 days at HA (4300 m). Fasting hematocrit (Hct), hemoglobin (Hb) and total circulating protein (TCP) concentrations at SL and on days 2, 7, 13, and 19 at HA were used to calculate %∆TCP and %∆PV. Mean [95%CI] measured %∆PV on HA2, 7, 13 and 19 was −2.5 [−8.2, 3.1], −11.0 [−16.6, −5.5], −11.7 [−15.9, −7.4], and −16.8 [−22.2, −11.3], respectively. %∆PV and %∆TCP were positively correlated (P < 0.001) at HA2, 7, 13, and 19 (r (2) = 0.77, 0.88, 0.78, 0.89, respectively). The model overpredicted mean [95% CI] decrease in %∆PV on HA2 (−12.5 [−13.9, −11.1]) and HA7 (−21.5 [−23.9, −19.1]), accurately predicted the mean decrease on HA13 (−14.3, [−20.0, −8.7]), and predicted a mean increase in %∆PV on HA19 (12.4 [−5.0, 29.8]). On HA2, 7, 13, and 19 only 2, 2, 6, and 1, respectively, of 17 individual measures of %∆PV were within 95% CI for predicted %∆PV. These observations indicate that PV responses to HA are largely oncotically mediated, vary considerably among individuals, and available quantitative models require refinement to predict %∆PV exhibited by individual sojourners. John Wiley and Sons Inc. 2019-03-28 /pmc/articles/PMC6437695/ /pubmed/30920186 http://dx.doi.org/10.14814/phy2.14051 Text en Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Young, Andrew J. Karl, James P. Berryman, Claire E. Montain, Scott J. Beidleman, Beth A. Pasiakos, Stefan M. Variability in human plasma volume responses during high‐altitude sojourn |
title | Variability in human plasma volume responses during high‐altitude sojourn |
title_full | Variability in human plasma volume responses during high‐altitude sojourn |
title_fullStr | Variability in human plasma volume responses during high‐altitude sojourn |
title_full_unstemmed | Variability in human plasma volume responses during high‐altitude sojourn |
title_short | Variability in human plasma volume responses during high‐altitude sojourn |
title_sort | variability in human plasma volume responses during high‐altitude sojourn |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437695/ https://www.ncbi.nlm.nih.gov/pubmed/30920186 http://dx.doi.org/10.14814/phy2.14051 |
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