Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosenberg, Yvonne J., Lewis, George K., Montefiori, David C., LaBranche, Celia C., Lewis, Mark G., Urban, Lori A., Lees, Jonathan P., Mao, Lingjun, Jiang, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437720/
https://www.ncbi.nlm.nih.gov/pubmed/30785963
http://dx.doi.org/10.1371/journal.pone.0212649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437720/
https://www.ncbi.nlm.nih.gov/pubmed/30785963
http://dx.doi.org/10.1371/journal.pone.0212649

Ejemplares similares