Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model

The anti-angiogenic soluble fms-like tyrosine kinase 1 (sFLT1) is one of the candidates in the progression of preeclampsia, often associated with fetal growth restriction (FGR). Therapeutic agents against preeclampsia with/without FGR, as well as adequate transgenic sFLT1 mouse models for testing su...

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Detalles Bibliográficos
Autores principales: Vogtmann, Rebekka, Kühnel, Elisabeth, Dicke, Nikolai, Verkaik-Schakel, Rikst Nynke, Plösch, Torsten, Schorle, Hubert, Stojanovska, Violeta, Herse, Florian, Köninger, Angela, Kimmig, Rainer, Winterhager, Elke, Gellhaus, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437783/
https://www.ncbi.nlm.nih.gov/pubmed/30949132
http://dx.doi.org/10.3389/fendo.2019.00165

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