Fetuin-A is also an adipokine

Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore...

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Autores principales: Jialal, Ishwarlal, Pahwa, Roma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437840/
https://www.ncbi.nlm.nih.gov/pubmed/30917813
http://dx.doi.org/10.1186/s12944-019-1021-8
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author Jialal, Ishwarlal
Pahwa, Roma
author_facet Jialal, Ishwarlal
Pahwa, Roma
author_sort Jialal, Ishwarlal
collection PubMed
description Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine.
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spelling pubmed-64378402019-04-08 Fetuin-A is also an adipokine Jialal, Ishwarlal Pahwa, Roma Lipids Health Dis Commentary Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine. BioMed Central 2019-03-27 /pmc/articles/PMC6437840/ /pubmed/30917813 http://dx.doi.org/10.1186/s12944-019-1021-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Jialal, Ishwarlal
Pahwa, Roma
Fetuin-A is also an adipokine
title Fetuin-A is also an adipokine
title_full Fetuin-A is also an adipokine
title_fullStr Fetuin-A is also an adipokine
title_full_unstemmed Fetuin-A is also an adipokine
title_short Fetuin-A is also an adipokine
title_sort fetuin-a is also an adipokine
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437840/
https://www.ncbi.nlm.nih.gov/pubmed/30917813
http://dx.doi.org/10.1186/s12944-019-1021-8
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