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Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

BACKGROUND: Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be overcome using autologous or allogeneic mesenchymal stem cells as carrier cells...

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Detalles Bibliográficos
Autores principales:	Draganov, Dobrin D., Santidrian, Antonio F., Minev, Ivelina, Nguyen, Duong, Kilinc, Mehmet Okyay, Petrov, Ivan, Vyalkova, Anna, Lander, Elliot, Berman, Mark, Minev, Boris, Szalay, Aladar A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437877/ https://www.ncbi.nlm.nih.gov/pubmed/30917829 http://dx.doi.org/10.1186/s12967-019-1829-z

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