Cargando…

First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

BACKGROUND: With poor prognosis and limited treatment options for advanced hepatocellular carcinoma (HCC), development of novel therapeutic agents is urgently needed. This single-arm phase I study sought to assess the safety and preliminary efficacy of icaritin in human as a potential oral immunothe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Ying, Li, Shu, Ding, Xiaoyan, Yue, Jian, Jiang, Jun, Zhao, Hong, Hao, Rui, Qiu, Weiliang, Liu, Kezhen, Li, Ying, Wang, Shengdian, Zheng, Limin, Ye, Bin, Meng, Kun, Xu, Binghe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437929/ https://www.ncbi.nlm.nih.gov/pubmed/30922248 http://dx.doi.org/10.1186/s12885-019-5471-1

Ejemplares similares

Icaritin Induces Anti-tumor Immune Responses in Hepatocellular Carcinoma by Inhibiting Splenic Myeloid-Derived Suppressor Cell Generation
por: Tao, Huimin, et al.
Publicado: (2021)

Icaritin‐induced immunomodulatory efficacy in advanced hepatitis B virus‐related hepatocellular carcinoma: Immunodynamic biomarkers and overall survival
por: Qin, Shu‐Kui, et al.
Publicado: (2020)

Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
por: Lu, Yi, et al.
Publicado: (2022)

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
por: Li, Haowen, et al.
Publicado: (2020)

Correction to: Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
por: Lu, Yi, et al.
Publicado: (2023)

Investigating the effect of Icaritin on hepatocellular carcinoma based on network pharmacology
por: Xue, Zhong, et al.
Publicado: (2023)

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
por: Lu, Pei-Hua, et al.
Publicado: (2017)

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma
por: Li, Hui, et al.
Publicado: (2021)

A Novel Semisynthetic Molecule Icaritin Stimulates Osteogenic Differentiation and Inhibits Adipogenesis of Mesenchymal Stem Cells
por: Sheng, Hui, et al.
Publicado: (2013)

A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway
por: Zhao, Hong, et al.
Publicado: (2015)

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis
por: Huang, Jun-ming, et al.
Publicado: (2023)

Icaritin inhibits decidualization of endometrial stromal cells
por: Le, Aiwen, et al.
Publicado: (2017)

Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia
por: Zhang, Ke, et al.
Publicado: (2018)

Induction of ROS and DNA damage-dependent senescence by icaritin contributes to its antitumor activity in hepatocellular carcinoma cells
por: Wang, Shikang, et al.
Publicado: (2019)

Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy
por: Yang, Xiao-Jing, et al.
Publicado: (2019)

Highly efficient bioconversion of icariin to icaritin by whole-cell catalysis
por: Lin, Yu, et al.
Publicado: (2023)

Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
por: Wu, Yue, et al.
Publicado: (2021)

Pharmacokinetics and metabolism of icaritin in rats by UPLC‐MS/MS
por: Huang, Zhen‐Wu, et al.
Publicado: (2019)

The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats
por: Jiang, Jun, et al.
Publicado: (2014)

Bioactive PLGA/tricalcium phosphate scaffolds incorporating phytomolecule icaritin developed for calvarial defect repair in rat model
por: Shi, Guang-Sen, et al.
Publicado: (2020)

Icaritin Synergistically Enhances the Radiosensitivity of 4T1 Breast Cancer Cells
por: Hong, Jinsheng, et al.
Publicado: (2013)

Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study
por: Yao, Dong, et al.
Publicado: (2012)

Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma
por: Wu, Ting, et al.
Publicado: (2015)

Preparation, Characterization, and In Vivo Evaluation of Amorphous Icaritin Nanoparticles Prepared by a Reactive Precipitation Technique
por: Tang, Cheng, et al.
Publicado: (2021)

Icaritin enhances the efficacy of cetuximab against triple-negative breast cancer cells
por: Yin, Li, et al.
Publicado: (2020)

What are the prospects for durable immune control?
por: Lelievre, J.D., et al.
Publicado: (2022)

HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia
por: Djurisic, Snezana, et al.
Publicado: (2014)

An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy
por: Zeng, Huating, et al.
Publicado: (2022)

Icaritin inhibits PD‐L1 expression by Targeting Protein IκB Kinase α
por: Mo, Dongliang, et al.
Publicado: (2021)

Icaritin Inhibits JAK/STAT3 Signaling and Growth of Renal Cell Carcinoma
por: Li, Shasha, et al.
Publicado: (2013)

Peripubertal Administration of Icariin and Icaritin Advances Pubertal Development in Female Rats
por: Kang, Hyun Ku, et al.
Publicado: (2012)

Antiosteoporosis Effects, Pharmacokinetics, and Drug Delivery Systems of Icaritin: Advances and Prospects
por: Gao, Lifang, et al.
Publicado: (2022)

Icaritin inhibits CDK2 expression and activity to interfere with tumor progression
por: Zhang, Chao, et al.
Publicado: (2022)

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3
por: Zhu, Shicong, et al.
Publicado: (2015)

Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2022)

Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells
por: Yang, Feifei, et al.
Publicado: (2023)

Durability of immune response after SARS-CoV-2 vaccination in patients with chronic liver disease
por: Song, Ruixin, et al.
Publicado: (2023)

Icaritin Improves Memory and Learning Ability by Decreasing BACE-1 Expression and the Bax/Bcl-2 Ratio in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice
por: Li, Yuan-Yuan, et al.
Publicado: (2020)

Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line
por: Li, Zi-Jian, et al.
Publicado: (2014)

Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity
por: He, Kun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lveur0bf70fu0b6elp4li4tp3q