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Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

BACKGROUND: Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androgen-dependent mechanisms of repression in PCa and may play...

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Detalles Bibliográficos
Autores principales:	Kamdar, Shivani, Isserlin, Ruth, Van der Kwast, Theodorus, Zlotta, Alexandre R., Bader, Gary D., Fleshner, Neil E., Bapat, Bharati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438015/ https://www.ncbi.nlm.nih.gov/pubmed/30917865 http://dx.doi.org/10.1186/s13148-019-0651-z

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