Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

BACKGROUND: The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related patholog...

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Detalles Bibliográficos
Autores principales: Zhang, Qing, Duplany, Agnès, Moncollin, Vincent, Mouradian, Sandrine, Goillot, Evelyne, Mazelin, Laetitia, Gauthier, Karine, Streichenberger, Nathalie, Angleraux, Céline, Chen, Jie, Ding, Shuzhe, Schaeffer, Laurent, Gangloff, Yann‐Gaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438346/
https://www.ncbi.nlm.nih.gov/pubmed/30461220
http://dx.doi.org/10.1002/jcsm.12336

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