15-keto-prostaglandin E(2) activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. However, the specific mechanisms by which C. neoformans manipulates host immunity...

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Detalles Bibliográficos
Autores principales: Evans, Robert J., Pline, Katherine, Loynes, Catherine A., Needs, Sarah, Aldrovandi, Maceler, Tiefenbach, Jens, Bielska, Ewa, Rubino, Rachel E., Nicol, Christopher J., May, Robin C., Krause, Henry M., O’Donnell, Valerie B., Renshaw, Stephen A., Johnston, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438442/
https://www.ncbi.nlm.nih.gov/pubmed/30921435
http://dx.doi.org/10.1371/journal.ppat.1007597

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