Coordination Chemistry of a Molecular Pentafoil Knot

[Image: see text] The binding of Zn(II) cations to a pentafoil (5(1)) knotted ligand allows the synthesis of otherwise inaccessible metalated molecular pentafoil knots via transmetalation, affording the corresponding “first-sphere” coordination Co(II), Ni(II), and Cu(II) pentanuclear knots in good yields (≥85%). Each of the knot complexes was characterized by mass spectrometry, the diamagnetic (zinc) knot complex was characterized by (1)H and (13)C NMR spectroscopy, and the zinc, cobalt, and nickel pentafoil knots afforded single crystals whose structures were determined by X-ray crystallography. Lehn-type circular helicates generally only form with tris-bipy ligand strands and Fe(II) (and, in some cases, Ni(II) and Zn(II)) salts, so such architectures become accessible for other metal cations only through the use of knotted ligands. The different metalated knots all exhibit “second-sphere” coordination of a single chloride ion within the central cavity of the knot through CH···Cl(–) hydrogen bonding and electrostatic interactions. The chloride binding affinities were determined in MeCN by isothermal titration calorimetry, and the strength of binding was shown to vary over 3 orders of magnitude for the different metal-ion–knotted-ligand second-sphere coordination complexes.