Mechanistic interaction study of 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione with bovine serum albumin by spectroscopic and molecular docking approaches

A synthesized and promising biologically hypoglycemic compound 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione (5e) was studied for its binding to a model protein (bovine serum albumin; BSA) by spectroscopic and molecular simulation approaches. Fluorescence studies revealed that 5e quenc...

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Detalles Bibliográficos
Autores principales: Alanazi, Mohammed M., Almehizia, Abdulrahman A., Bakheit, Ahmed H., Alsaif, Nawaf A., Alkahtani, Hamad M., Wani, Tanveer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438701/
https://www.ncbi.nlm.nih.gov/pubmed/30976176
http://dx.doi.org/10.1016/j.jsps.2018.12.001

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