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Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival. Recent studies have attempted to prevent the interaction of RAS/GTP with RAS guanine nucleotide exchange factors (GEFs), impair RAS-e...

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Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Wang, Zhihua, Ma, Xiaoyao, Yang, Shengnan, Hu, Xueyan, Tao, Jin, Hou, Yuanyuan, Bai, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438844/ https://www.ncbi.nlm.nih.gov/pubmed/30976491 http://dx.doi.org/10.1016/j.apsb.2018.11.002

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