Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging...

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Detalles Bibliográficos
Autores principales: Chen, ZiSheng, Tian, Dongbo, Liao, Xiaowen, Zhang, Yifei, Xiao, Jinghua, Chen, Weiping, Liu, Qingxia, Chen, Yun, Li, Dongmin, Zhu, Lianyu, Cai, Shaoxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438929/
https://www.ncbi.nlm.nih.gov/pubmed/30967777
http://dx.doi.org/10.3389/fphar.2019.00260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438929/
https://www.ncbi.nlm.nih.gov/pubmed/30967777
http://dx.doi.org/10.3389/fphar.2019.00260

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