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Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging...

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Detalles Bibliográficos
Autores principales:	Chen, ZiSheng, Tian, Dongbo, Liao, Xiaowen, Zhang, Yifei, Xiao, Jinghua, Chen, Weiping, Liu, Qingxia, Chen, Yun, Li, Dongmin, Zhu, Lianyu, Cai, Shaoxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438929/ https://www.ncbi.nlm.nih.gov/pubmed/30967777 http://dx.doi.org/10.3389/fphar.2019.00260

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