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Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor

The roles of Plant Homeodomain (PHD) fingers in catalysis of histone modifications are unknown. We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination of histone H2B at lysine120 (H2BK120Ub). Puri...

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Detalles Bibliográficos
Autores principales:	Adhikary, Santanu, Chakravarti, Deepavali, Terranova, Christopher, Sengupta, Isha, Maitituoheti, Mayinuer, Dasgupta, Anirban, Srivastava, Dushyant Kumar, Ma, Junsheng, Raman, Ayush T., Tarco, Emily, Sahin, Aysegul A., Bassett, Roland, Yang, Fei, Tapia, Coya, Roy, Siddhartha, Rai, Kunal, Das, Chandrima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438984/ https://www.ncbi.nlm.nih.gov/pubmed/30923315 http://dx.doi.org/10.1038/s41467-019-08986-5

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