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The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats
Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with high-fat, high-carbohydrate diet was performed on diet obese rats and joint...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439084/ https://www.ncbi.nlm.nih.gov/pubmed/30840227 http://dx.doi.org/10.1007/s12192-019-00976-2 |
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author | Stygar, Dominika Skrzep-Poloczek, Bronisława Romuk, Ewa Chełmecka, Elżbieta Poloczek, Jakub Sawczyn, Tomasz Maciarz, Justyna Kukla, Michał Karcz, Konrad W. Jochem, Jerzy |
author_facet | Stygar, Dominika Skrzep-Poloczek, Bronisława Romuk, Ewa Chełmecka, Elżbieta Poloczek, Jakub Sawczyn, Tomasz Maciarz, Justyna Kukla, Michał Karcz, Konrad W. Jochem, Jerzy |
author_sort | Stygar, Dominika |
collection | PubMed |
description | Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with high-fat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. The normalisation of circulating levels and liver concentrations of HSP70 and HSP90 may be achieved in a combination of DJOS procedure with a proper dietary plan. |
format | Online Article Text |
id | pubmed-6439084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-64390842019-04-15 The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats Stygar, Dominika Skrzep-Poloczek, Bronisława Romuk, Ewa Chełmecka, Elżbieta Poloczek, Jakub Sawczyn, Tomasz Maciarz, Justyna Kukla, Michał Karcz, Konrad W. Jochem, Jerzy Cell Stress Chaperones Original Paper Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with high-fat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. The normalisation of circulating levels and liver concentrations of HSP70 and HSP90 may be achieved in a combination of DJOS procedure with a proper dietary plan. Springer Netherlands 2019-03-06 2019-03 /pmc/articles/PMC6439084/ /pubmed/30840227 http://dx.doi.org/10.1007/s12192-019-00976-2 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Stygar, Dominika Skrzep-Poloczek, Bronisława Romuk, Ewa Chełmecka, Elżbieta Poloczek, Jakub Sawczyn, Tomasz Maciarz, Justyna Kukla, Michał Karcz, Konrad W. Jochem, Jerzy The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title_full | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title_fullStr | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title_full_unstemmed | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title_short | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
title_sort | influence of high-fat, high-sugar diet and bariatric surgery on hsp70 and hsp90 plasma and liver concentrations in diet-induced obese rats |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439084/ https://www.ncbi.nlm.nih.gov/pubmed/30840227 http://dx.doi.org/10.1007/s12192-019-00976-2 |
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